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LCSN EA 1069

Development of molecules with therapeutic or phytosanitary properties and recovery of agricultural resources.


The LCSN has 14 researchers and research professors, 4 technicians associated, 15 doctoral students, postdoctoral trainees and seconded foreign professors. This is a unique multidisciplinary organisation (chemists, biochemists, biologists). The LCSN has two missions; "application of chemistry" (research aim) and "chemical and biological development of agricultural production" (professional aim). Doctoral candidates are trained with the research school ED 258. The lab is member of GRD CNRS 3049 « médicaments photoactivables-photochimiothérapie (PHOTOMED) »

Activities and products

Oriented towards the production and biological assessment of natural substances, the methods of synthesis and implementation are mainly"clean chemistry" methods, which do not use any toxic solvents. The LCSN is dedicated to developing natural substances in two main directions:


  • The production of molecules with therapeutic or phytosanitary properties, with the synthesis and biological assessment of nucleoside and oligonucleotide analogues as antivirals (anti-HIV, anti-Herpes simplex); the synthesis and structural analysis of colorants (porphyrins and analogues) as vectors into photosensitizers involved in the phototherapy of cancers and in bactericidia; even the production of prebiotic products from enzymatic hydrolysates of polysaccharides of plant origin and the biological assessment in vitro of synthesised molecules.
  • Environmentally aimed non-food recovery of agricultural resources (farming or forestry) with the chemical modification of the polyglucidic components contained in agricultural (bran, straw, bark, etc), industrial (wood), or household (paper, card, etc.) waste, with a view to obtaining biodegradable plastic materials, or producing micropollutant filters through the modification of sawdust and bark; as well as obtaining new tensioactive ingredients, extracting polysaccharides and the structural determination and modification of the cellulosic and hemicellulosic content of wood by genetic improvement (plant glycobiology); even the study of the ability of plants to depollute industrial wastelands contaminated with metallic and/or organic pollutants (phytoremediation). The laboratory develops technological service provision or partnerships with regional and national companies Iooking to use their analytical expertise, or develop original experimental protocols in the sector of chemical or biological development and synthesis of natural substances.


The LCSN is the author of approximately 100 publications (national, and above ail international journals), 50 presentations in conferences, 20 conferences, three patents and sorne thirty-odd theses. lt has initiated national and international collaboration projects (Universities of Tirana, Neuchatel, Lublin, Belfast, Minnesota, Kénitra, Giessen, Mitsuama, Hull, Vilnius, Universität für Boden Kultin de Vienne, Trois Rivière (Canada)). lt has forged important relations with institutional bodies (DRAF, ADEME, ANVAR, Limousin wood network, etc) and industries (Limagrain, Aventis, L'OREAL SILAB, SOTHYS, etc). Five companies in incubation are associated to the laboratory.


Vincent SOL, Professeur, Directeur du laboratoire
Université de Limoges / Faculté des Sciences et techniques / 123, Avenue Albert Thomas / 87060 Limoges
Cedex Tél. 33(0)555457475/ Fax 33(0)555457202 /